CBD and CBG together yes or no? What are the differences?

Hemp contains over 100 different cannabinoids, including CBG, a key component contributing to the creation of THC and CBD, the two best known and most studied cannabinoids. Interest in non-psychoactive cannabinoids, such as CBD and CBG, is growing steadily due to the potential health benefits they can offer without the altering effects typical of THC.

CBG is currently the focus of much research for its properties and the synergy it can create together with CBD, a phenomenon known as entourage effect. This effect suggests that the interaction between CBD and CBG mutually enhances their properties, opening up new perspectives for a combined use of these cannabinoids.

In this article, we will explore in detail the characteristics of CBG, the potential benefits of its combination with CBD and the possible adverse effects, providing a complete overview on this increasingly studied component.

What is the difference between CBD and CBG?

CBD (cannabidiol) and CBG (cannabigerol) are both cannabinoids found in the cannabis plant, but differ in their structural characteristics and in the way they interact with the plant. 

CBD is one of the most abundant and well studied cannabinoids, while CBG is less present and usually considered a “basic cannabinoid” or “precursor”, as other compounds, including CBD and THC, are derived from it through enzymatic reactions during plant growth.

Chemically, CBD and CBG belong to structurally similar families, but CBG-A (the acid form of CBG) converts to other cannabinoids as it matures, being present only in small amounts in the mature plant. This makes CBG rarer and more expensive to isolate, while CBD is more abundant and therefore more readily available. 

Also at the molecular level, the two cannabinoids bind differently to receptors of the endocannabinoid system, with CBD interacting mainly with CB2 receptors and CBG showing action on a wider range of receptors, including CB1 and CB2 receptors.

What is CBG-A?

CBG-A, or cannabigerolic acid, was first identified in 1964 by scientist Y. Gaoni. This compound represents one of the first cannabinoids formed in the cannabis plant, serving as a precursor for other important cannabinoid acids. During the ripening phase, through the action of specific enzymes, CBG-A is transformed into THC-A, CBD-A and CBC-A, which are known for their therapeutic properties.

CBG-A belongs to the class of terpeno-phenols, compounds found in cannabis that are distinguished by their chemical structure and wide application potential. In particular, CBG-A contains a phenolic ring with antibacterial and antimicrobial properties, while its two lipophilic chains – the n-alkyl chain and the terpenoic chain – give the compound a low solubility in water, facilitating tissue penetration. These characteristics make CBG-A of interest for pharmacological research, given the possibility of using it for targeted and innovative treatments.

CBD properties

CBD is one of the most studied and used cannabinoids in legal cannabis, known for its therapeutic properties and lack of psychoactive effects, unlike THC.

Due to these characteristics, CBD is widely used in the medical and wellness fields for multiple benefits. These include:

• Anti-inflammatory: CBD modulates the inflammatory response of the body by interacting with the endocannabinoid system, especially with CB2 receptors located in immune cells. This interaction is able to reduce inflammatory processes by reducing the release of cytokines and other pro-inflammatory molecules.
• Analgesics: CBD possesses pain-relieving properties due to its ability to act on vanilloid receptors and pain receptors present in the central and peripheral nervous system. Through this interaction, CBD is able to reduce pain perception, being effective for chronic pain conditions such as neuropathy, migraine and joint pain.
• Anxiolytics: CBD can reduce anxiety levels without inducing significant side effects, such as drowsiness and addiction. It acts on serotonin receptors, promoting a state of calm and stabilising mood. These anxiolytic effects have been shown to be beneficial for those suffering from anxiety disorders, stress and insomnia, improving mental well-being and supporting sleep quality.
• Antipsychotics: CBD can stabilise neurotransmitter activity in the brain, showing promise as a complementary treatment for psychotic conditions such as schizophrenia and bipolar disorder.
• Anti-emetic: CBD counteracts nausea and vomiting through interaction with serotonergic receptors, offering natural support for those undergoing therapies such as chemotherapy, reducing these debilitating side effects. 
• Antioxidants: CBD protects cells from oxidative stress by neutralising free radicals and slowing down cell damage. This antioxidant property is valuable for skin health, helping to counteract the signs of ageing and maintaining cellular integrity. 

CBG properties

CBG (cannabigerol), although less well known, is gaining attention for its unique therapeutic potential and its role as a precursor to other cannabinoids, including CBD and THC. Often referred to as the ‘mother molecule’ of cannabis, CBG possesses relevant properties in health care.

These include:

• Antibacterial: CBG has proven particularly effective against antibiotic-resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA). CBG’s ability to interfere with bacterial life processes without damaging human cells makes it a promising alternative to traditional antibiotics in clinical settings.
• Neuroprotective: CBG has demonstrated neuroprotective potential through its action of stimulating neurogenesis and protecting neuronal cells from oxidative stress. This cannabinoid may help prevent cell death in patients suffering from neurodegenerative diseases such as Alzheimer’s, Parkinson’s and Huntington’s.
• Anti-inflammatory: CBG is known for its anti-inflammatory properties, which manifest themselves by regulating the immune response and reducing inflammation in affected tissues. This effect is particularly beneficial for chronic conditions such as inflammatory bowel disease and psoriasis, improving symptoms without the side effects of conventional drugs.
• Antispasmodic: CBG helps reduce muscle cramps and spasms, making it particularly useful for conditions involving muscle spasticity, such as multiple sclerosis and some forms of epilepsy. This antispasmodic effect helps to relax muscles and improve mobility, offering a higher quality of life to those suffering from these conditions.
• Appetite-stimulants: CBG has been shown to stimulate appetite by acting on specific receptors in the brain that regulate hunger and food consumption. This effect may be particularly useful for those suffering from loss of appetite due to diseases such as cancer or HIV, or for those with eating disorders, offering natural support to improve nutrient intake.
• Hypotensive: Preliminary studies suggest that CBG may help reduce blood pressure through interaction with endocannabinoid receptors that regulate vasodilation. This hypotensive effect may support cardiovascular health and reduce the risk of hypertension, making CBG a possible natural option for those seeking improved blood pressure management.

CBD and CBG together: tips and considerations

When combining CBD and CBG, it is important to assess certain aspects in order to make the most of the potential of the two cannabinoids. Combined use may offer greater benefits due to the entourage effect, but requires attention to dosage, side effects and mode of intake. Below are some tips and considerations for safe and effective use.

Dosage

The optimal dosage of CBD and CBG may vary depending on several factors, such as 

• Body weight
• Experience with cannabinoids
• Desired effect

In general, those new to the combined use of CBD and CBG should start with a lower dose and gradually increase until a suitable dosage is found. 

Studies suggest that CBG can amplify the effects of CBD, so combined intake may require lower amounts than using one alone. In addition, factors such as the type of disorder being treated and individual reaction to the product are key elements in determining the ideal dose.

Side effects

Although CBD and CBG are generally well tolerated, they can present side effects, especially at high dosages. Possible side effects include:

• Fatigue
• Dry mouth
• Headache
• Nausea

The combination of CBD and CBG may exacerbate these symptoms in some people, so it is advisable to monitor one’s response and reduce the dose if unwanted effects occur. Consulting a doctor before starting is always a good practice, especially for those taking other medications.

Benefits

The combined intake of CBD and CBG is appreciated for the synergistic effect known as the ‘entourage effect’. This interaction appears to enhance the benefits of both cannabinoids, offering a more complete action. 

Together, they may favour:

• Relaxation
• Reduced inflammation
• Pain relief
• Supported mental health in situations of anxiety or stress

Some studies indicate that the combination of the two may even have a neuroprotective effect and support intestinal health.

Modalities of intake

CBD and CBG can be taken together in different ways, depending on personal preferences and needs. Common options include sublingual oils, which allow for rapid absorption, and capsules, ideal for those who prefer a measured dose. In addition, some prefer the use of vaporisers or edible supplements.

CBD and CBG: what does science say?

Future prospects for the joint use of CBD and CBG are promising, especially due to research interest in the entourage effect, the natural synergy generated between these cannabinoids. 

Ongoing studies are exploring how this combination may amplify therapeutic benefits for various conditions, including neurodegenerative disorders, chronic inflammation and mental health problems. The neuroprotective action, already observed separately for CBD and CBG, could be particularly effective in the treatment of diseases such as Parkinson’s and Alzheimer’s when used together.

In addition, the combined use of CBD and CBG is being investigated for the management of chronic pain and gut health, with potential application for complex conditions such as IBD and arthritis. 

With the advancement of extraction technologies and the growing knowledge of cannabinoid chemistry, it is expected that more and more specific products will become available to exploit the benefits of this combination, including highly concentrated oils and metered capsules. These prospects open the way for new natural treatments and offer a more complete alternative to traditional remedies for many health conditions.

CBD and CBG products

CBD and CBG products, such as broad spectrum and full spectrum oils, offer a range of therapeutic benefits depending on the composition and type of extraction used. Broad spectrum oils contain various cannabinoids, such as CBD, CBG and other beneficial compounds of the cannabis plant, but exclude THC. This makes them ideal for those seeking relaxing and anti-inflammatory effects without the risk of psychoactivity, perfect for those wishing to take advantage of the entourage effect without the THC.

The oils can have different concentrations of CBD, to be chosen according to the intensity and severity of the symptoms. You can find them on our CBD Shop Maria CBD Oil!

For low intensity, you can use CBD Oil 5% or 10%:

For medium to high intensity, CBD oil 15% or 20%:

Finally, for very high intensity, CBD oil 25% or 30% is definitely for you:

An alternative to oil could be CBD capsules, which are very convenient for their ease of use and the possibility of having precise dosages to take at any time.

Visit our Maria CBD Oil website now to find the right product for you!